Furthermore, we detected the mRNA and protein expression levels of 8 epi-PCGs (ETV4, SH2B3, FATE1, GRK5, MALL, HRH2, SEMA3G and SLC10A6) in 4 human kidney cancer cell lines (786-O, A498, Caki-1 and ACHN) and the normal human renal tubular epithelial cell line HK2. The gene discussed is SH2B3; the disease is kidney cancer.