Surprisingly, when we explored the correlation between YBX3 and HEIH expression and the outcomes of digestive tract cancers, we found that, in most digestive tract cancers, such as ESAD, STAD, and COAD, the expression of the two genes presented diametrically opposed relationships with prognosis—namely, a higher expression of YBX3 predicted a worse prognosis in digestive tract cancers, while a higher expression of HEIH predicted a better prognosis of the same cancer types (Supplementary Figures S1–3C, D). The gene discussed is YBX3; the disease is cancer.