HEIH and esophageal cancer: The upregulation of lncRNA-HEIH was first observed in hepatocellular carcinoma (15); subsequently, its role in gastric adenocarcinoma, melanoma, non-small-cell lung cancer, ovarian cancer, nasopharyngeal cancer, and esophageal cancer was successively discovered, and lncRNA-HEIH showed an upregulated pattern in all of these tumors (16–20).