We found that YBX3 expression was positively correlated with the tumor infiltration of Tregs in BLCA, COAD, KIRC, KIRP, LGG, LIHC, PRAD, THCA, and THYM; tumor infiltration of CAFs in nearly all cancer types except ACC, BRCA (basal and Her2 molecular subtypes), CESC, DLBC, (HPV+)HNSC, LUSC, MESO, OV, SARC, UCS, and UVM; and tumor infiltration of MDSCs in ACC, BLCA, BRCA (except LumB molecular subtypes), CESC, CHOL, ESCA, HNSC (without HPV+), KIRC, KIRP, LIHC, LUAD, LUSC, PAAD, SKCM, STAD, TGCT, THCA, and UCEC (Figure 6B). This evidence concerns the gene YBX3 and cancer.