YBX3 and adrenal cortex carcinoma: It is worth mentioning that, for tumors that occur in the upper body, such as ACC, HNSC, and lung cancers (including LUSC and LUAD), a higher YBX3 expression indicates a worse prognosis in terms of OS, DSS, and PFI, all with P <0.05 (Supplementary Figure S1–3B).