YBX3 and cancer: The characterization of YBX3 and its regulatory lncRNA HEIH in terms of diagnostic and prognostic significance, the immuno-oncologic context of the TME and therapeutic responses across cancers, and especially further exploring them in colon cancer both experimentally and bioinformatically add another dimension to our understanding of their critical roles in tumor progression and suppression and offer an experimental and integrative basis for deeper verification of their molecular biology and even their future clinical application in cancer therapies.