Since HLA-DRB1*03:01 is also associated to AIH and ASC, and HLA-DRB1*13 is also associated to ASC, these alleles predispose to AIH, ASC and PSC: whether PSC represents a late stage phenotype of ASC, remains an open question; of note, both diseases lack female preponderance (62). The gene discussed is HLA-DRB1; the disease is Tako-tsubo cardiomyopathy.