Non-neurological and non-hematological toxicities included pyrexia (78.8%), hypoxia (36.4%), hypotension (3.0%), cardiac failure (6.0%), acute kidney injury (15.2%), pneumonia (12.1%), increase of alanine transaminase (24.2%) and hyperbilirubinemia (3.0%). The gene discussed is GPT; the disease is susceptibility to pneumonia measurement.