The prediction of increased viral infection may be due, in part, to downregulation of the antiviral related molecules IFITM3, and TRIM22. Interferon-induced transmembrane proteins (IFITM) can inhibit HIV entry and viral protein synthesis, and IFITM3 was reported to be involved in antiviral responses by trafficking vesicles containing viruses into the lysosome for degradation (100–102). Here, TRIM22 is linked to viral infectious disease.