In order to achieve a comprehensive collection of patient cases, we took advantage of vast numbers of open-source data from the major cancer projects such as TCGA and CPTAC for exploration of the interactive expression patterns between PSEN1 and PD-L1 as well as the multiple correlations of PSEN1 with PD-L1 nuclear translocation, which overcame the obstacle of our own limited sample collection. This evidence concerns the gene CD274 and cancer.