PSEN1 and colon adenocarcinoma: To further uncover the cellular composition of the infiltrates affected by PSEN1 in COAD, we performed correlation analyses of PSEN1 with individual immune subsets and found that levels of PSEN1 were negatively correlated with naive CD8+ T (Spearman’s rho = −0.138, p < 0.05) and CD4+ Th1 cells (Spearman’s rho = −0.272, p < 0.001), but positively correlated with Tregs (Spearman’s rho = 0.312, p < 0.001) and CAFs (Spearman’s rho = 0.255, p < 0.001) (Figure 4C).