Interestingly, results showed that the expression of zc3h12a was significantly promoted at 6 h after infection, but the level of ssa-miR-146a-5p in the spleen and exosomes showed a delayed promotion at 16 h after infection, suggesting that the expression of zc3h12a in spleen at 16 h was inhibited by ssa-miR-146-5p, which may be delivered from the plasma exosomes since ssa-miR-146-5p in exosomes and the spleen synchronized to high levels at 16 h and the ZC3H12A located on the ER was more approachable to exosomes, depending on the mechanisms of exosome uptake (81). The gene discussed is ZC3H12A; the disease is infection.