In urine-derived EVs (CD63-labeled vesicles), both TMPRSS2-ERG and a prostate cancer biomarker, Prostate Cancer Antigen (PCA-3) mRNA, were found, indicating that the mRNA composition of EVs is informative and may give prospective prostate cancer biomarkers (Figure 2) (125). Here, TMPRSS2 is linked to Familial prostate cancer.