For example, EVs produced from cancer cells overexpressing wild-type EGFR can activate the vasculature by delivering the antigen to adjacent endothelial cells, resulting in the production of Vascular Endothelial Growth Factor (VEGF) and subsequent autocrine signaling via its receptor Vascular Endothelial Growth Factor Receptor (VEGFR2) (60). Here, VEGFA is linked to cancer.