Concomitantly, due to the utmost importance of Gleason score in PCa management, it is the high-grade disease (Gleason≥7) that dictates the need for aggressive treatment options, thus we have included this important metric throughout the study and concluded that the levels of serum TRAIL and IL-10, are clinically useful for the prediction of Gleason≥7 AG PCa in PHI-based multivariable prediction models. The gene discussed is IL10; the disease is posterior cortical atrophy.