As a correlate to increased immune cell activation within the tumor following ONP-302 treatment, the percentage of IL-15+ cells increased within both the spleen and tumor (Figures 5B, 6B) over time, and there was an increase in the percentage of activated NK cells (CD244+, granzyme B+, perforin+, and PD-1+) at both sites (Figures 5D, 6D). The gene discussed is PRF1; the disease is neoplasm.