IL-15 is a key cytokine for driving the activation of NK and CD8+ T cells (20) further suggesting that NK cells and CD8+ T cells play a key role in ONP-302-induced control of tumor growth as supported by our finding that treatment led to increased infiltrates of NK1.1+ cells and CD8+ T cells near areas of cellular necrosis (Figure 4E). Here, CD8A is linked to neoplasm.