In our study, by analyzing different datasets and performing qRT-PCR experiments, we found that compared with normal controls, CST1 was highly expressed in the inflamed nasal mucosa and nasal polyps in ACRSwNP patients, highly expressed in nasal polyps in CRSwNP patients (but less than the ACRSwNP group), and highly expressed in the nasal mucosa and bronchial epithelium of asthma patients. The gene discussed is CST1; the disease is chronic rhinosinusitis with nasal polyps.