Gene expression levels of 12 hub genes (ALOX5AP, AQP9, AZGP1, CCL13, EMR3, F13A1, GAPT, MUC7, NCF2, PIP, PRR4, and STATH) were validated by qRT-PCR using nasal polyps from ACRSwNP patients and nasal mucosa from healthy controls (Figure 8A). This evidence concerns the gene PIP and Nasal polyposis.