In COVID-19 interaction, the TF–miRNA network showed that E2F1, MAX, EGR1, YY1, and SRF were the highly expressed TFs, and hsa-miR-19b, hsa-miR-495, hsa-miR-340, hsa-miR-101, and hsa-miR-19a were among significant miRNAs (Figure 9B). The gene discussed is EGR1; the disease is COVID-19.