ARHGEF12 and COVID-19: Conversely, SARS-CoV-2 infection suppressed the expression of genes associated with transcription factors (MAFF) (47), erythropoiesis (ARHGEF12) (48), membrane neddylation (DCUN1D3) (49), a global regulator of transcription (DR1) (50), and cytochrome-c oxidase activity (MT-CO1) (51) in both COVID-19 patients and recovered humans (Figure 2D).