After synchronization of MM cells at the G1/S restriction point using the CDK4/6 inhibitor palbociclib, OTUD6B‐ and LIN28B‐depleted cells remained in G1 upon cell cycle release whereas control cells readily progressed to S‐ and G2/M‐phases (Fig 4A and B). Here, OTUD6B is linked to Miyoshi myopathy.