Although there was no significant difference in the serum lumican level between the ARDS group, the ventilated control group, and the spontaneously breathing control group (p > 0.05; Fig. 1A), the lumican level in BALF was significantly higher in the ARDS group (12,968.47 pg/mL [5387.91–34,446.62] pg/mL) than in the ventilated controls (2472.10 pg/mL [1070.86–3887.35 pg/mL]) and spontaneously breathing controls (677.87 pg/mL [291.27–2047.76 pg/mL]; p < 0.0001; Fig. 1B). The gene discussed is LUM; the disease is acute respiratory distress syndrome.