Lastly, we characterized mutational profiles of the 380 baseline patients and demonstrated that concurrent gene alterations, such as SMAD4 mutations and MYC copy-number gain, were more frequently associated with KIF5B-RET than CCDC6-RET fusions in baseline RET-rearranged NSCLC patients. The gene discussed is KIF5B; the disease is non-small cell lung carcinoma.