BRAF and melanoma: PD-1 blockade is also effective in patients with BRAF-mutant melanoma; 6.5-year OS rates in CheckMate 067 were 57%, 43%, and 25% in patients with BRAF-mutant tumors and 46%, 42%, and 22% in those with BRAF-wild-type tumors in the combination, nivolumab, and ipilimumab groups, respectively.