CD4 and AIDS: A study in New York twenty years ago among 504 ambulatory patients with AIDS demonstrated that neither gender nor CD4+ T-cell count was associated with symptom number or distress [25].Similar other studies also revealed that symptoms in HIV are present throughout the disease trajectory regardless of CD4+ T-cell count and stage classification and the burden of symptoms has not been carefully examined in terms of its association with clinical staging or treatment status [26, 27].