Multivariate Cox model analysis showed that the age (HR = 1.836, 95% CI 1.090–3.094, P = 0.022), TNM stage (HR = 2.407, 95% CI 1.392–4.162, P = 0.002), pathological stage (HR = 2.271, 95% CI 1.287–4.006, P = 0.005), and METTL3 expression level (HR = 2.243, 95% CI 1.309–3.843, P = 0.003) could be used as independent risk factors for prognosis prediction of PC patients (Table 2). The gene discussed is METTL3; the disease is pachyonychia congenita.