MPO and inflammatory response: The involvement of α7nAChRs in the pathological development of intestinal inflammation was first reported in a vagotomy mouse model, and it was found that vagotomy increased the DAI, macroscopic and histological scores, MPO activity, and proinflammatory cytokine levels in colitis colon tissue in TNBS or DSS induced acute colitis mouse models (Ghia 2006).