The immune score of each colon adenocarcinoma patient were calculated using the following formula:immune score=SCT*0.0651+SCTR*0.2110+IL7*−0.3138+ULBP1*0.0825+IL17A*−0.0783+STC2*0.1352+EREG*−0.0785+ULBP2*0.0324+NGF*−0.0265+XCL1*0.0813+RORC*−0.1411+CXCL14*0.0017+MCHR2*0.1496+NRG1*−0.0562+UCN*0.1865+FABP4*−0.0186+LEP*0.0364+C8G*0.0091+UCN3*−0.1071+OXTR*−0.0069+HSPA1A*0.1246+HSPA1L*0.1010+ORM1*−0.1399+TDGF1*−0.0429+NOX5*0.1017+GH1*0.3369. The gene discussed is HSPA1L; the disease is colon adenocarcinoma.