The commonly used drugs in clinical practice including FGFR inhibitor, VEGFR inhibitors, and EGFR inhibitor et al Increased evidences showed that FGFRs were the driving genes of various cancers, which were involved in the maintenance of the malignant characteristics of tumor cells in a “cell autonomy” manner and in the multiple steps of tumorigenesis and development.18 This evidence concerns the gene KDR and cancer.