Antigen‐specific CD4+ T cells within artificial TLSs could be cytotoxic in B16 melanoma and support anti‐tumor responses.[40, 41] Given that effector T cells are initially recruited in the early phase of TLS formation,[39] SVF SPH with mDCs transplantation efficiently summoned effector T cells into both renal capsule and tumor mass. This evidence concerns the gene CD4 and neoplasm.