They and other variables were then separately introduced into univariate Cox regression, as shown in Table 2; patients with poor performance status (ECOG 2~), presence of extrahepatic metastasis, multiple liver metastasis, high level of CEA (≥ 10 ng/mL), high level of CA19‐9 (≥35 U/mL), high tumor grade (G3~4) as well as high LCS were at high risk of death while compared to their counters (all p values <0.05). Here, CEACAM5 is linked to neoplasm.