PIT has been used to treat local tumors as well as metastasis and prevents recurrence.9 In our laboratory, we have reported the usefulness of PIT with an anti-CEA antibody conjugated to 700-nm dye for pancreatic cancer nude mouse models.10–12 Initially, only PIT was used for the treatment of pancreatic cancer10 or bright-light surgery along with PIT.11 This evidence concerns the gene CEACAM3 and pancreatic neoplasm.