APOE and Mental deterioration: Surprisingly we did not find any effect of the APOE genotype on the mid-frontal theta dynamics while theta dynamics was correlated to amyloid load and amyloid load is known to be correlated with the APOE genotype [92, 93], and pre-symptomatic carriers of the APOE ɛ4 allele with a higher amyloid load show a more rapid cognitive decline as compared to APOE ɛ4 non-carriers [94].