INS and type 2 diabetes mellitus: On the other hand, we studied the early effects of SGLT-2i on myocardial metabolism and perfusion using highly sophisticated and gold standard methods to assess insulin sensitivity (euglycemic hyperinsulinemic clamp), myocardial and whole body metabolism (glucose uptake calculated by FDG PET/CT during euglycemic hyperinsulinemic clamp), MBF and MFR (by PET/CT with 13N-ammonia) in a highly selected study population (T2D patients with a narrow HbA1c range and CAD not requiring revascularization or clinically stable after PCI).