In addition to the vasodilatory action of SGLT-2i treatment, accumulating evidence suggests that dapagliflozin reduces cardiac remodeling by regulating the TGF-β1/Smad signaling in a non-glucose-lowering dependent manner [45] and attenuates advanced glycation end product induced inflammation and apoptosis in diabetic nephropathy through AMPK-mTOR mediated autophagy pathway [46]. This evidence concerns the gene MTOR and diabetic kidney disease.