NPPB and hydrops fetalis: For this purpose, the treatment effect estimate in the PARADIGM-HF biomarker sub-study population from a model with treatment group, region, and baseline log(NT-proBNP) as explanatory variables (hazard ratio of 0.81) was compared with the treatment effect estimate from the same model, but with the inclusion of change from baseline in log(NT-proBNP) at Month 1 as an additional covariate (Table 4).