TF and Tangier disease: Most of the recruited chronically transfused SCD patients (86%) had normal-to-mild pancreatic iron overload, confirming that they are less likely to develop pancreatic iron overload compared to patients with TM; this is likely because iron released by transfusion and hemolysis is efficiently handled by effective erythropoiesis [37], thus keeping transferrin saturations [38] and non-transferrin-bound iron (NTBI) levels low [39].