However, there was evidence for an association of a genetically-predicted effect of IL-6 activity on CRP levels with smoking (ORIL-6/CRP–Smk = 1.06 (1.03–1.09), p < 0.001, but not depression (ORIL–6/CRP-Dep = 0.93 (0.85–1.02), p = 0.126 (Table 3 and Supplementary Table 3). Here, IL6 is linked to major depressive disorder.