The core mechanism in the malignant transformation of MCL has been demonstrated to be a translocation involving chromosomes 11 and 14 (t(11;14)(q13,32), CCND1/IGH), leading to the overexpression of CCND1 protein [5, 61, 62], while other cases may be driven by a CCND2 or CCND3 translocation with IGK or IGL [63]. This evidence concerns the gene CCND1 and mantle cell lymphoma.