Further analysis also showed that CDDP treatment alone lowered the frequencies of effector T cells (including IFN-γ + CD4 + T cells and IFN-γ + CD8 + T cells), while I + C restored the frequencies of tumor-infiltrating effector T cells, suggesting that the combination therapy reversed the suppression of tumor-specific T cells induced by CDDP. This evidence concerns the gene CD4 and neoplasm.