Similarly, using a dietary model of NAFLD in which mice were fed WDF 16 weeks, we observed impairment of the polyamine biosynthesis and Dhps-Dohh-Eif5aH pathways exemplified by decreased levels of Dhps and Dohh mRNA and protein, and Eif5aH protein during early NASH (Fig. 1d, e). The gene discussed is DHPS; the disease is metabolic dysfunction-associated steatotic liver disease.