The survival analysis of the GSE87371 dataset using R language revealed that the lower mRNA expression levels of euchromatic histone lysine methyltransferase 1 (EHMT1), nuclear receptor binding SET domain protein (NSD) 1, Wolf-Hirschhorn syndrome candidate 1-like 1(WHSC1L1/NSD3) and SET domain containing 1 A histone lysine methyltransferase (SETD1A) were significantly associated with the poor progression-free survival (PFS) and OS of DLBCL patients (Fig. S1A, B). The gene discussed is SETD1A; the disease is diffuse large B-cell lymphoma.