Multivariate analysis confirmed that high SMYD3 protein expression was an independent prognostic marker for poor PFS (HR = 1.728; 95% CI, 1.070–2.791; P = 0.025; Table 2) and OS (HR = 2.645; 95% CI, 1.534–4.558; P < 0.001; Table 3) in patients with DLBCL. The gene discussed is SMYD3; the disease is diffuse large B-cell lymphoma.