pTDP-43 and pTau are known components of GVD granules [36, 82], which predominantly occur in ADNC but also to a lesser extent in non-AD tauopathies, including argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), in TDP-43 proteinopathies, such as ALS and FTLD, as well as in normal aging [41, 70, 78, 79]. Here, TARDBP is linked to proteostasis deficiencies.