Our findings indicated that SARS-CoV-2 infection-induced ACE2 degradation could be rescued by Baf A1 treatment (Supplementary Fig. 4a), and ACE2 colocalized with early endosome at early stage of infection, but colocalized with late endosome at late stage of SARS-CoV-2 infection (Supplementary Fig. 4b, c). This evidence concerns the gene ACE2 and infection.