Furthermore, considering the strong effects of BAF disruption on proliferation through cell cycle arrest and downregulation of one of the most-wanted neuroblastoma therapeutic targets, cyclin D1, these findings reveal BAF complex structural disruption as a potential therapeutic strategy for the treatment of metastatic high-risk neuroblastoma and urge for the design and development of pharmacological structural disruptors of this chromatin remodeller. The gene discussed is BANF1; the disease is neuroblastoma.