Structural disruption of the BAF complex, achieved by silencing of its essential subunits ARID1A and ARID1B, exerted an epigenomic reprogramming in neuroblastoma cells, resulting in the repression of a wide expression program involving invasiveness-related genes such as integrins, cadherins, and key mesenchymal regulators, leading to the impairment of metastatic invasion, an effect that is potentially exploitable in a therapeutic strategy for the treatment of metastatic neuroblastoma. This evidence concerns the gene ARID1B and neuroblastoma.