HRs of MSMO1 and SPP1 were higher than 1, which were risk factors for CSCC prognosis, while HRs of ISCU, GCH1, EEFSEC, RHOG, LSP1 and TCN2 were lower than 1, which could be protective factors for CSCC prognosis. The gene discussed is SPP1; the disease is skin squamous cell carcinoma.