MAPT and Alzheimer disease: Recent studies have shown that tau-PET binding in the anterior hippocampus is directly related to memory function [49], early Aβ deposition occurs in the posterior-medial system, such as the posterior cingulate cortex and the precuneus, in preclinical AD [50], and altered dFC between the hippocampus and amygdala is consistent with high pathological tau deposition [51].