Periostin regulates myofibroblast differentiation and is persistently overexpressed in abnormal scars and other benign fibrous tissues proliferating with fibroblasts [28], while soft substrates Inhibit its expression, also in the presence of TGF-β1 stimulation (Figure 4C), it showed that the soft substrates may inhibit the differentiation and contraction of hFFs, and combined with the soft substrates inhibiting the proliferation of hFFs, these phenomena have certain significance for the treatment of skin scarring, sclerosis, fibrosis and other diseases related to the proliferation of FBs. This evidence concerns the gene TGFB1 and fibrosis.