Furthermore, changes in transcriptional factor cascades, such as increased expression of adipogenic genes (PPAR-γ, aFABP, lipogenic genes (FAS), and macrophage-specific markers (CD68, F4/80), have been reported in obesity-related studies (Chang et al. 2015; Kim et al. 2012). This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.