CAMK2G and endothelial dysfunction: Furthermore, ROS promote endothelial dysfunction through the oxidation of crucial cellular signalling proteins such as tyrosine phosphatases.6 The overproduction of ROS and oxidation of CaMKII may lead to the abnormal up-regulation of the late sodium current (INa-Late) and abnormal Ca2+ handling.7 This study investigated whether MIF modulates the electrophysiological characteristics of the PV by regulating ionic currents and Ca2+ homeostasis through the activation of CaMKII signalling.