Future studies are required to further understand the physiological intricacies of Bmal1 in the context of aging, with the following main to‐be‐explored aspects: (1) the signaling pathway network of Bmal1 mechanisms in aging‐related diseases needs to be established, (2) several studies have shown that Bmal1 deficiency is involved in the occurrence and development of many other diseases not discussed in this review such as dilated cardiomyopathy (Lefta et al., 2012; Li, Li, et al., 2020) and cancer (Stokes et al., 2021; Wang et al., 2019). The gene discussed is BMAL1; the disease is dilated cardiomyopathy.