Further, the aberrant expression of Bmal1 mRNA and protein in the mouse hippocampus can be induced by Aβ (Wang, Lv, et al., 2018), while it has also been reported that the Bmal1 loss can in turn accelerates the amyloid plaques accumulation (Kress et al., 2018). This evidence concerns the gene BMAL1 and amyloidosis.