Recently, it has been documented that the “conventional pan‐melanoma cocktail” can be used to diagnose EAML because the melanocyte markers HMB‐45, Melan‐A, SOX10, and tyrosinase can be expressed in some EAML, and because S100 is usually not expressed in EAML, it can be used to differentiate from melanoma, but this method requires further testing.35, 36, 37, 38. The gene discussed is PMEL; the disease is melanoma.