In 63 HIV‐associated DLBCL cases with complete follow‐up data, univariate analysis showed that age ≥ 60 (p = 0.001), elevated LDH (p = 0.019), advanced stage (p = 0.046), high IPI score (3–5) (p = 0.032), high ECOG‐PS score (2–4) (p = 0.026) and lower CD4 cell count (<200/μl) (p = 0.049) and received less than two cycles of chemotherapy (p = 0.019) were predictive of worse PFS. Here, CD4 is linked to diffuse large B-cell lymphoma.