Importantly, when gender, age, treatment options, and TNFAIP3 mutation status were included in univariate and multivariate Cox regression for survival analysis, the results suggested that TNFAIP3 mutation was an independent prognostic predictor of OS for T‐ALL patients (HR = 3.14; 95% CI: 1.34–7.38; p = 0.008; Table 2). The gene discussed is TNFAIP3; the disease is acute lymphoblastic leukemia.