Data identified that in the low HER2 cohort and different ATM levels (high/low); ABL1, SMAD4, RB1 and PARP1 were significantly upregulated and AKT1, AKT2, TSC2, RPTOR and mTOR were significantly downregulated in bladder cancer (Table S4). Here, SMAD4 is linked to urinary bladder carcinoma.