We observed that HER2 overexpression or/and amplified ERBB2 of bladder tumours strongly associated with clinicopathological variables characteristic of poor prognosis, including high tumour grade, tumour stage, late disease stage, tumour shape, lymph node and metastasis in bladder cancer, our data are consistent with previous reports.18, 49. The gene discussed is ERBB2; the disease is urinary bladder carcinoma.