Early activation of extrafollicular autoimmune B cells in SLE, which includes different ABC subsets (Jenks et al., 2018; Rubtsov et al., 2011), depends on cell‐intrinsic TLR7 signaling (Fillatreau et al., 2021; Teichmann et al., 2013). Here, TLR7 is linked to systemic lupus erythematosus.