MFN1 and Parkinson disease: In PD, α-syn aggregation in the neuron is capable to perturb the cycle of mitochondrial fusion and fission because of its deleterious effect on mitochondrial associated proteins including mitofusin 1 and 2 (Mfn1/2), DRP1, and MFF, correlative with an increase in aberrant mitochondria and inefficiency of neuronal signaling[89–90].