There was only two retrospective studies published in 2017 and 2021 that suggested that if anti-VEGF drugs are used to treat DME, combine micropulse laser treatment after macular edema reduces to mild to moderate, then the number of intravitreal injections can be reduced compared to anti-VEGF monotherapy group [10, 11]. The gene discussed is VEGFA; the disease is macular retinal edema.