At last, ESR ≥ 27.5 mm/h, fever, lymphocyte ratio ≥ 91.5%, unilateral pleural effusion was eliminated by the model, And age ≤ 46.5 years, male, no cancer, positive T-SPOT, CRP ≥ 52.8 mg/L, ADA ≥ 24.5 U/L were accepted into the final binary logistic regression model. The gene discussed is ADA; the disease is cancer.