scRNA-seq and scTCR-seq analyses in conjunction with flow cytometric analysis of CSF cells reveal that clonally expanded CD8+ T cells from AD patients are CD45RA+CD27−CCR7−/lowCD127−CD161−PD-1− TEMRA cells expressing high levels of granzyme genes, NKG7, CST7, CCL4 and CCL5 [4]. The gene discussed is CD8A; the disease is Alzheimer disease.