scRNA-seq and scTCR-seq analyses show that clonally expanded CD8 T cells in MS express higher levels of CD8 effector function–related molecules including granzymes A and K, NKG7, PFN1, CST7, CCL5, and CCL4 and express lower levels of SELL (CD62L), which are CCR7−/lowCD127− [7]. Here, CD8A is linked to myeloid sarcoma.